1 METABOLISM 1.01 amino-acid metabolism 1.01.01 amino-acid biosynthesis 1.01.04 regulation of amino-acid metabolism 1.01.10 amino-acid degradation (catabolism) 1.01.99 other amino-acid metabolism activities 1.02 nitrogen and sulphur metabolism 1.02.01 nitrogen and sulphur utilization 1.02.04 regulation of nitrogen and sulphur utilization 1.02.99 other nitrogen and sulphur metabolism activities 1.03 nucleotide metabolism 1.03.01 purine-ribonucleotide metabolism 1.03.04 pyrimidine-ribonucleotide metabolism 1.03.07 deoxyribonucleotide metabolism 1.03.10 metabolism of cyclic and unusual nucleotides 1.03.13 regulation of nucleotide metabolism 1.03.16 polynucleotide degradation 1.03.16.01 RNA degradation 1.03.19 nucleotide transport 1.03.99 other nucleotide-metabolism activities 1.04 phosphate metabolism 1.04.01 phosphate utilization 1.04.04 regulation of phosphate utilization 1.04.07 phosphate transport 1.04.99 other phosphate metabolism activities 1.05 C-compound and carbohydrate metabolism 1.05.01 C-compound and carbohydrate utilization 1.05.01.01 C-compound, carbohydrate catabolism 1.05.01.01.01 sugar, glucoside, polyol and carboxylate catabolism 1.05.01.01.03 C-2 compound, organic acid and fatty acid catabolism 1.05.01.03 C-compound, carbohydrate anabolism 1.05.01.03.02 polysaccharide biosynthesis 1.05.01.03.04 aminosaccharide biosynthesis 1.05.01.05 autotrophic CO2-fixation 1.05.04 regulation of C-compound and carbohydrate utilization 1.05.07 C-compound, carbohydrate transport 1.05.99 other carbohydrate metabolism activities 1.06 lipid, fatty-acid and isoprenoid metabolism 1.06.01 lipid, fatty-acid and isoprenoid biosynthesis 1.06.01.01 phospholipid biosynthesis 1.06.01.05 fatty acid biosynthesis 1.06.01.07 isoprenoid biosynthesis 1.06.01.07.11 tetracyclic and pentacyclic triterpenes (steroids and hopanoids) biosynthesis 1.06.04 breakdown of lipids, fatty acids and isoprenoids 1.06.07 lipid, fatty-acid and isoprenoid utilization 1.06.10 regulation of lipid, fatty-acid and isoprenoid biosynthesis 1.06.13 lipid and fatty-acid transport 1.06.99 other lipid, fatty-acid and isoprenoid metabolism activities 1.07 metabolism of vitamins, cofactors, and prosthetic groups 1.07.01 biosynthesis of vitamins, cofactors, and prosthetic groups 1.07.04 utilization of vitamins, cofactors, and prosthetic groups 1.20 secondary metabolism 1.20.01 metabolism of primary metabolic sugars derivatives 1.20.01.01 biosynthesis of secondary monosaccharides 1.20.01.07 biosynthesis of glycosides 1.20.13 biosynthesis of derivatives of homoisopentenyl pyrophosphate 1.20.15 biosynthesis of derivatives of dehydroquinic acid, shikimic acid and chorismic acid 1.20.17 biosynthesis of secondary products derived from primary amino acids 1.20.35.01 biosynthesis of stilbenes, flavonoids 1.20.37 biosynthesis of peptide derived compounds 1.20.99 other secondary metabolism activities 2 ENERGY 2.01 glycolysis and gluconeogenesis 2.07 pentose-phosphate pathway 2.07.01 pentose-phosphate pathway oxidative branch 2.10 tricarboxylic-acid pathway 2.11 electron transport and membrane-associated energy conservation 2.11.01 electron transport proteins 2.11.03 ATP synthesis proteins 2.11.05 accessory proteins of electron transport and membrane-associated energy conservation 2.11.99 other electron transport and membrane-associated energy conservation proteins 2.13 respiration 2.13.01 anaerobic respiration 2.13.05 aerobic respiration 2.16 fermentation 2.16.01 alcohol fermentation 2.19 metabolism of energy reserves (glycogen, trehalose) 2.22 glyoxylate cycle 2.25 oxidation of fatty acids 2.30 photosynthesis 2.30.01electron transport proteins of photosynthesis 2.30.03 accessory proteins of photosynthetic electron transport 2.99 other energy generation activities 3 CELL GROWTH, CELL DIVISION AND DNA SYNTHESIS 3.13 meiosis 3.16 DNA synthesis and replication 3.19 recombination and DNA repair 3.99 other cell growth, cell division and DNA synthesis activities 4 TRANSCRIPTION 4.01 rRNA transcription 4.01.01 rRNA synthesis 4.01.04 rRNA processing 4.01.99 other rRNA-transcription activities 4.03 tRNA transcription 4.03.01 tRNA synthesis 4.03.03 tRNA processing 4.03.06 tRNA modification 4.03.99 other tRNA-transcription activities 4.05 mRNA transcription 4.05.01 mRNA synthesis 4.05.01.01 general transcription activities 4.05.01.04 transcriptional control 4.05.03 mRNA processing (splicing) 4.05.05 mRNA processing (5'-, 3'-end processing, mRNA degradation) 4.05.99 other mRNA-transcription activities 4.99 other transcription activities 5 PROTEIN SYNTHESIS 5.01 ribosomal proteins 5.04 translation 5.07 translational control 5.10 tRNA-synthetases 5.99 other protein-synthesis activities 6 PROTEIN DESTINATION 6.01 protein folding and stabilization 6.04 protein targeting, sorting and translocation 6.07 6.07 protein modification 6.10 assembly of protein complexes 6.13 proteolysis 6.13.01 cytoplasmic and nuclear degradation 6.13.04 lysosomal and vacuolar degradation 6.13.07 other proteolytic degradation 6.99 other protein-destination activities 7 TRANSPORT FACILITATION 7.01 channels/pores 7.04 ion transporters 7.04.01 metal ion transporters (Cu, Fe, etc.) 7.04.03 other cation transporters (Na, K, Ca , NH4, etc.) 7.04.99 anion transporters (Cl, SO4, PO4, etc.) 7.07 C-compound and carbohydrate transporters 7.22 transport ATPases 7.25 ABC transporters 7.99 other transport facilitators 8 CELLULAR TRANSPORT AND TRANSPORT MECHANISMS 8.01 nuclear transport 8.02 chloroplast transport 8.04 mitochondrial transport 8.07 vesicular transport (Golgi network, etc.) 8.10 peroxisomal transport 8.13 vacuolar transport 8.16 extracellular transport (secretion) 8.19 cellular import 8.22 cytoskeleton-dependent transport 8.99 other intracellular-transport activities 9 CELLULAR BIOGENESIS (proteins are not localized to the corresponding organelle) 9.01 biogenesis of cell wall (cell envelope) 9.03 biogenesis of plasma membrane 9.04 biogenesis of cytoskeleton 9.99 chloroplast biogenesis 10 CELLULAR COMMUNICATION/SIGNAL TRANSDUCTION 10.01 intracellular communication 10.03 unspecified signal transduction 10.05 receptor proteins 10.99 other unspecified signal transduction activities 11 CELL RESCUE, DEFENSE, CELL DEATH AND AGEING 11.01 stress response 11.03DNA repair 11.03.01nucleotide excision repair 11.05 Disease, virulence and defense 11.05.01 resistance proteins 11.05.03 defense related proteins 11.05.05 virulence, disease factors 11.05.05.99 other virulence, disease factors 11.05.99 other disease and defense related proteins 11.07 detoxificaton 11.07.01 detoxification involving cytochrome P450 11.07.03 detoxification by modification 11.07.99 other detoxification 11.10 cell death and ageing 11.10.09 degradation of exogenous ester compounds 11.99 other cell rescue activities 13 IONIC HOMEOSTASIS 13.04 ionic homeostasis 30 CELLULAR ORGANIZATION (proteins are localized to the corresponding organelle) 30.01 organization of cell wall 30.02 organization of plasma membrane 30.03 organization of cytoplasm 30.04 organization of cytoskeleton 30.07 organization of endoplasmatic reticulum 30.08 organization of Golgi 30.09 organization of intracellular transport vesicles 30.10 nuclear organization 30.13 organization of chromosome structure 30.16 mitochondrial organization 30.19 peroxisomal organization 30.25 vacuolar and lysosomal organization 30.26 chloroplast organization 30.99 other cellular organization 98 CLASSIFICATION NOT YET CLEAR-CUT 99 UNCLASSIFIED PROTEINS